(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate
CAS No.:1359969-32-6
Molecular Formula:C₂₇H₃₂N₂O₆
Molecular Weight:480.561
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

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Chemical Property of (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

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Technology Process of (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

There total 1 articles about (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1359969-23-5
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoic acid

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1359969-32-6
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ol3002199

Reference yield: 75.0%

: 1359969-32-6
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

: 1359969-36-0
(S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoic acid

Guidance literature:: (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate; With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; pH=7;
DOI:10.1021/ol3002199

Reference yield:

: 1359969-32-6
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

: 1359969-39-3
(5S,8S,11S)-methyl 11-(azidomethyl)-8-isobutyl-3,6,9-trioxo-1-phenyl-5-(4-(prop-2-yn-1-yloxy)benzyl)-2-oxa-4,7,10-triazadodecan-12-oate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C

1.2: pH 7

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol3002199