4-Fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol

Base Information

Chemical Name:4-Fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol
CAS No.:381229-75-0
Molecular Formula:C₈H₅ClF₄O
Molecular Weight:228.574
Hs Code.:
DSSTox Substance ID:DTXSID101219899

Synonyms:381229-75-0;Benzenemethanol, 3-chloro-4-fluoro-5-(trifluoromethyl)-;4-fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol;[3-chloro-4-fluoro-5-(trifluoromethyl)phenyl]methanol;SCHEMBL24852109;DTXSID101219899;3-Chloro-4-fluoro-5-(trifluoromethyl)benzenemethanol

Suppliers and Price of 4-Fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:227.9965051
Heavy Atom Count:14
Complexity:196

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=C(C(=C1C(F)(F)F)F)Cl)CO

Technology Process of 4-Fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol

There total 2 articles about 4-Fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 381229-48-7
4-fluoro-3-chloro-5-(trifluoromethyl)benzoic acid

: 381229-75-0
4-fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol

Guidance literature:: With borane; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1021/jm0103108

Reference yield:

: 67515-55-3
4-fluoro-3-(trifluoromethyl)benzoic acid

: 381229-75-0
4-fluoro-3-chloro-5-(trifluoromethyl)benzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1.1: s-BuLi; TMEDA / cyclohexane / 0.5 h / -90 °C

1.2: hexachloroethane / cyclohexane; tetrahydrofuran / -90 - 25 °C

2.1: BH₃ / tetrahydrofuran / 2 h / 25 °C

With N,N,N,N,-tetramethylethylenediamine; borane; sec.-butyllithium; In tetrahydrofuran; cyclohexane;
DOI:10.1021/jm0103108