1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole

Base Information

• Chemical Name: 1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole
• CAS No.: 122484-74-6
• Molecular Formula: C₂₃H₂₈N₄O₃
• Molecular Weight: 408.5
• Mol file: 122484-74-6.mol

Synonyms:1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole

Chemical Property of 1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole

There total 7 articles about 1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

[1,4]diazepan-5-one (34376-54-0) + 2-chloro-1-(2-ethoxyethyl)-5-phenylmethoxy-1H-benzimidazole (122484-70-2) → 1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole (122484-74-6)

Guidance literature:

at 170 ℃; for 6h;

DOI:10.1248/cpb.37.962

Reference yield:

3-nitro-4-chlorophenol (610-78-6) → 1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole (122484-74-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 64 percent / K₂CO₃ / dimethylformamide / 5 h / 90 °C

2: 47.8 g / 11 h / Heating

3: 43.1 g / zinc dust, HCl / ethanol / 10 - 35 °C

4: 6 h / 160 °C

5: 66 percent / POCl₃ / 1 h / Heating

6: 29 percent / 6 h / 170 °C

With hydrogenchloride; potassium carbonate; zinc; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.962

Reference yield:

4-benzyloxy-2-nitro-chlorobenzene (79035-13-5) → 1-(2-ethoxyethyl)-2-(hexahydro-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole (122484-74-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 47.8 g / 11 h / Heating

2: 43.1 g / zinc dust, HCl / ethanol / 10 - 35 °C

3: 6 h / 160 °C

4: 66 percent / POCl₃ / 1 h / Heating

5: 29 percent / 6 h / 170 °C

With hydrogenchloride; zinc; trichlorophosphate; In ethanol;

DOI:10.1248/cpb.37.962

upstream raw materials:

[1,4]diazepan-5-one

2-chloro-1-(2-ethoxyethyl)-5-phenylmethoxy-1H-benzimidazole

3-nitro-4-chlorophenol

4-benzyloxy-2-nitro-chlorobenzene

Downstream raw materials:

1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-5-oxo-1H-1,4-diazepin-1-yl)-5-phenylmethoxy-1H-benzimidazole