Bicyclo[2.2.2]octane-2-carboxylicacid, 2-amino-, (2S)-

Base Information

Chemical Name:Bicyclo[2.2.2]octane-2-carboxylicacid, 2-amino-, (2S)-
CAS No.:763904-78-5
Molecular Formula:C₉H₁₅NO₂
Molecular Weight:169.224
Hs Code.:
DSSTox Substance ID:DTXSID90452059
Mol file:763904-78-5.mol

Synonyms:763904-78-5;Bicyclo[2.2.2]octane-2-carboxylicacid, 2-amino-, (2S)-;DTXSID90452059;(S)-2-Aminobicyclo[2.2.2]octane-2-carboxylicacid;(S)-2-Aminobicyclo[2.2.2]octane-2-carboxylic acid

Suppliers and Price of Bicyclo[2.2.2]octane-2-carboxylicacid, 2-amino-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Bicyclo[2.2.2]octane-2-carboxylicacid, 2-amino-, (2S)-

Chemical Property:

PSA：63.32000
LogP:1.67890
XLogP3:-1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:169.110278721
Heavy Atom Count:12
Complexity:209

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2CCC1CC2(C(=O)O)N
Isomeric SMILES:C1CC2CCC1C[C@]2(C(=O)O)N

Technology Process of Bicyclo[2.2.2]octane-2-carboxylicacid, 2-amino-, (2S)-

There total 9 articles about Bicyclo[2.2.2]octane-2-carboxylicacid, 2-amino-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

: (S)-2-Benzoylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

: 763904-78-5
(2S)-2-aminobicyclo[2.2.2]octane-2-carboxylic acid

Guidance literature:: With hydrogenchloride; for 48h; Heating;

Reference yield: 40.0%

: 366452-32-6
C₂₅H₃₂N₂O₃

: 763904-78-5
(-)-(1R,2R,4S)-2-aminobicyclo[2.2.2]octane-2-carboxylic acid

Guidance literature:: C₂₅H₃₂N₂O₃; With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 9h; under 760 Torr;

With hydrogenchloride; Dowex 50X-100; In acetic acid; toluene; for 24h; Heating;
DOI:10.1016/S0040-4020(01)00553-1

Reference yield:

: C₂₀H₂₃NO₂

: 763904-78-5
(-)-(2R)-2-aminobicyclo<2.2.2>octane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2 N aq. HCl / tetrahydrofuran

2: H₂ / Pd/C / 760 Torr

3: 6N aq. HCl / 150 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/S0957-4166(99)00061-0