5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

Base Information

• Chemical Name: 5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid
• CAS No.: 220481-70-9
• Molecular Formula: C₅₈H₁₀₂N₈O₁₂
• Molecular Weight: 1103.49
• Mol file: 220481-70-9.mol

Synonyms:5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

Chemical Property of 5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

There total 4 articles about 5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

11-{4-[4,8-bis-tert-butoxycarbonyl-11-(4-ethoxycarbonyl-butyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester → 5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid (220481-70-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2003.10.036

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid (220481-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 4 h / 20 °C / Cooling with ice

2: potassium carbonate; sodium iodide / acetonitrile / Reflux; Inert atmosphere

3: sodium hydroxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 4 h

With N-benzyl-trimethylammonium hydroxide; potassium carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

1,4,8,11-Tetraazacyclotetradecane (295-37-4) → 5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid (220481-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 4 h / 20 °C / Cooling with ice

2: potassium carbonate; sodium iodide / acetonitrile / Reflux; Inert atmosphere

3: sodium hydroxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 4 h

With N-benzyl-trimethylammonium hydroxide; potassium carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

1,4-bis(bromomethyl)benzene

1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

5-<4,8-bis(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoic ethyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine