2-Ethyl-2,7-diazaspiro[4.4]nonane

Base Information

• Chemical Name: 2-Ethyl-2,7-diazaspiro[4.4]nonane
• CAS No.: 763883-32-5
• Molecular Formula: C9H18 N2
• Molecular Weight: 154.255
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50390529
• ChEMBL ID: CHEMBL1616622
• Mol file: 763883-32-5.mol

Synonyms:2-ethyl-2,7-diazaspiro[4.4]nonane;763883-32-5;2,7-Diazaspiro[4.4]nonane, 2-ethyl-;2-ETHYL-2,7-DIAZASPIRO[4,4]NONANE;SCHEMBL1509491;CHEMBL1616622;DTXSID50390529;STK661676;AKOS005530984;2-Ethyl-2,7-diaza-spiro[4,4]nonane;2-Ethyl-2,7-diaza-spiro[4.4]nonane;BP-11226

Chemical Property of 2-Ethyl-2,7-diazaspiro[4.4]nonane

Chemical Property:

• PSA: 15.27000
• LogP: 0.95840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 154.146998583
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

99%min ^*data from raw suppliers

2-Ethyl-2,7-diazaspiro[4.4]nonane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCC2(C1)CCNC2

Technology Process of 2-Ethyl-2,7-diazaspiro[4.4]nonane

There total 1 articles about 2-Ethyl-2,7-diazaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane dihydrochloride (91189-30-9) → 2-ethyl-2,7-diazaspiro<4.4>nonane (763883-32-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00170a035

Reference yield: 60.0%

4-iodo-2-methyl-6-nitroaniline (532934-93-3) + 2-ethyl-2,7-diazaspiro<4.4>nonane (763883-32-5) → 4-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-2-methyl-6-nitro-phenylamine (936939-28-5)

Guidance literature:

With potassium phosphate; ethylene glycol; copper(l) iodide; In isopropyl alcohol; at 90 ℃; for 19h;

Reference yield:

2-ethyl-2,7-diazaspiro<4.4>nonane (763883-32-5) → 4-[2-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-ethyl]-phenylamine (936939-25-2)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol; for 16h;

upstream raw materials:

2-ethyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane dihydrochloride

Downstream raw materials:

4-[2-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-ethyl]-phenylamine

2-ethyl-7-[2-(4-nitro-phenyl)-ethyl]-2,7-diaza-spiro[4.4]nonane

4-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-2-methyl-6-nitro-phenylamine

Refernces