6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

Base Information

Chemical Name:6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
CAS No.:1166810-44-1
Molecular Formula:C₁₇H₁₆F₄N₆
Molecular Weight:380.348
Hs Code.:

Synonyms:6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

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Chemical Property of 6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

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Technology Process of 6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

There total 4 articles about 6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 338748-56-4
6-(piperazin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

: 459-57-4
4-fluorobenzaldehyde

: 1166810-44-1
6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: With (polystyrylmethyl)trimethylammonium cyanoborohydride; In dichloromethane; acetic acid; at 20 ℃; for 40h;
DOI:10.1016/j.bmcl.2013.02.056

Reference yield:

: 40971-95-7
6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

: 1166810-44-1
6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 11 h / 70 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: (polystyrylmethyl)trimethylammonium cyanoborohydride / dichloromethane; acetic acid / 40 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; acetic acid;
DOI:10.1016/j.bmcl.2013.02.056

Reference yield:

: 1166819-50-6
tert-butyl 4-(3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperazine-1-carboxylate

: 1166810-44-1
6-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: (polystyrylmethyl)trimethylammonium cyanoborohydride / dichloromethane; acetic acid / 40 h / 20 °C

With trifluoroacetic acid; In dichloromethane; acetic acid;
DOI:10.1016/j.bmcl.2013.02.056