{(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

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Chemical Name:{(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol
CAS No.:438002-58-5
Molecular Formula:C₅₂H₇₀O₈SSi
Molecular Weight:883.274
Hs Code.:

{(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

Synonyms:{(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

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Chemical Property of {(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

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Technology Process of {(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

There total 13 articles about {(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 58921-09-8
diethylaluminum benzenethiolate

: 438002-56-3
[(2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-2-((R)-1-benzyloxy-2-(2R,4aR,8aS)-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxin-2-yl-ethyl)-2-methyl-tetrahydro-pyran-3-yloxy]-triisopropyl-silane

: 438002-58-5
{(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

Guidance literature:: In hexane; dichloromethane; at 20 ℃; for 6.5h;
DOI:10.1021/jo010974p

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 438002-58-5
{(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

Guidance literature:: Multi-step reaction with 11 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 14 h / 20 °C

2.1: p-toluenesulfonic acid hydrate / methanol; CH₂Cl₂ / 19.5 h / 20 °C

3.1: NaH / dimethylformamide / 0.25 h / 20 °C

3.2: 35.53 g / dimethylformamide / 16 h / 20 °C

4.1: 5.53 g / aq. OsO₄; N-methylmorpholine N-oxide / acetone / 19 h / 20 °C

5.1: NaIO₄ / tetrahydrofuran; H₂O / 9 h / 20 °C

6.1: 5.24 g / MgBr₂*Et₂O / CH₂Cl₂ / 2 h / -78 - 20 °C

7.1: NaH / dimethylformamide / 0.5 h / 20 °C

7.2: 100 percent / dimethylformamide / 4.5 h / 0 °C

8.1: osmiumm tetraxide; N-methylmorpholine N-oxide / acetone; H₂O / 9 h / 20 °C

9.1: NaIO₄ / tetrahydrofuran; H₂O / 1 h / 20 °C

10.1: 2.60 g / scandium trifluoromethanesulfonate / benzene / 31.5 h / 20 °C

11.1: 64 percent / CH₂Cl₂; hexane / 6.5 h / 20 °C

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; magnesium bromide; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo010974p

Reference yield:

: 131310-61-7
(2R,4aR,6S,7R,8aS)-6-Methyl-2-phenyl-6-vinyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 438002-58-5
{(2R,3S)-3-[(1S,3R)-3-Benzyloxy-3-((2S,3R,5S,6R)-5-benzyloxy-6-benzyloxymethyl-2-methyl-3-triisopropylsilanyloxy-tetrahydro-pyran-2-yl)-1-phenylsulfanyl-propoxy]-3,6-dihydro-2H-pyran-2-yl}-methanol

Guidance literature:: Multi-step reaction with 11 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 14 h / 20 °C

2.1: p-toluenesulfonic acid hydrate / methanol; CH₂Cl₂ / 19.5 h / 20 °C

3.1: NaH / dimethylformamide / 0.25 h / 20 °C

3.2: 35.53 g / dimethylformamide / 16 h / 20 °C

4.1: 5.53 g / aq. OsO₄; N-methylmorpholine N-oxide / acetone / 19 h / 20 °C

5.1: NaIO₄ / tetrahydrofuran; H₂O / 9 h / 20 °C

6.1: 5.24 g / MgBr₂*Et₂O / CH₂Cl₂ / 2 h / -78 - 20 °C

7.1: NaH / dimethylformamide / 0.5 h / 20 °C

7.2: 100 percent / dimethylformamide / 4.5 h / 0 °C

8.1: osmiumm tetraxide; N-methylmorpholine N-oxide / acetone; H₂O / 9 h / 20 °C

9.1: NaIO₄ / tetrahydrofuran; H₂O / 1 h / 20 °C

10.1: 2.60 g / scandium trifluoromethanesulfonate / benzene / 31.5 h / 20 °C

11.1: 64 percent / CH₂Cl₂; hexane / 6.5 h / 20 °C

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; magnesium bromide; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo010974p