((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Base Information

Chemical Name:((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester
CAS No.:203636-33-3
Molecular Formula:C₃₇H₄₄N₄O₇
Molecular Weight:656.779
Hs Code.:

((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Synonyms:((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

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Chemical Property of ((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

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Technology Process of ((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

There total 7 articles about ((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94744-50-0
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

: 203636-33-3
((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / thionyl chloride / CH₂Cl₂ / 24 h

2: 1-hydroxybenzotriazole potassium salt / CH₂Cl₂

With thionyl chloride; 1-Hydroxy-1,2,3-benzotriazole potassium salt; In dichloromethane;
DOI:10.1016/S0040-4039(97)10724-9

Reference yield:

: 1738-68-7
Gly-OBz

: 203636-33-3
((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole potassium salt / CH₂Cl₂

2: 4-aminomethylpiperidine / 0.5 h

3: 1-hydroxybenzotriazole potassium salt / CH₂Cl₂

4: 4-aminomethylpiperidine / 0.5 h

5: 1-hydroxybenzotriazole potassium salt / CH₂Cl₂

With 4-Aminomethylpiperidine; 1-Hydroxy-1,2,3-benzotriazole potassium salt; In dichloromethane;
DOI:10.1016/S0040-4039(97)10724-9

Reference yield:

: 74939-28-9,100937-80-2,120744-31-2
H-Val-Gly-OBn

: 203636-33-3
((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxybenzotriazole potassium salt / CH₂Cl₂

2: 4-aminomethylpiperidine / 0.5 h

3: 1-hydroxybenzotriazole potassium salt / CH₂Cl₂

With 4-Aminomethylpiperidine; 1-Hydroxy-1,2,3-benzotriazole potassium salt; In dichloromethane;
DOI:10.1016/S0040-4039(97)10724-9