[2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester

Base Information

Chemical Name:[2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester
CAS No.:911392-84-2
Molecular Formula:C₃₅H₅₈O₄Si₂
Molecular Weight:599.014
Hs Code.:

[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3<i>H</i>-cyclopenta[<i>a</i>]naphthalen-3-yl]-acetic acid <i>tert</i>-butyl ester

Synonyms:[2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester

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Chemical Property of [2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester

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Technology Process of [2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester

There total 1 articles about [2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 911392-90-0
2-[2-(tert-butyldimethylsilyloxymethyl-7-hydroxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]acetic acid tert-butyl ester

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 911392-84-2
[2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester

Guidance literature:: With dmap; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1002/anie.200601003

Reference yield:

: 911392-84-2
[2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester

: 911392-92-2
(3'S,3a'S,9b'S,1''S,2''S,4'''S)-2-{2-[3-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-hydroxy-2-methyl-3-oxo-propyl]-7-triisopropylsilyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / TsOH*H₂O / methanol / 4 h / 0 °C

2: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 2.5 h / 0 °C

3: 89 percent / n-Bu₂BOTf; Et₃N / CH₂Cl₂ / -75 - -25 °C

With di-n-butylboryl trifluoromethanesulfonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; 2: Dess-Martin oxidation / 3: Evams aldol addition;
DOI:10.1002/anie.200601003

Reference yield:

: 911392-84-2
[2-(tert-butyl-dimethyl-silanyloxymethyl)-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl]-acetic acid tert-butyl ester

: 911393-00-5
{2-[3-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-oxo-propyl]-7-triisopropylsilanyloxy-3a,9b-dihydro-3H-cyclopenta[a]naphthalen-3-yl}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / TsOH*H₂O / methanol / 4 h / 0 °C

2: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 2.5 h / 0 °C

3: 89 percent / n-Bu₂BOTf; Et₃N / CH₂Cl₂ / -75 - -25 °C

4: 84 percent / DMAP / CH₂Cl₂ / 20 h / 20 °C

With dmap; di-n-butylboryl trifluoromethanesulfonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; 2: Dess-Martin oxidation / 3: Evams aldol addition;
DOI:10.1002/anie.200601003