1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine

Base Information

Chemical Name:1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine
CAS No.:1100768-39-5
Molecular Formula:C₁₇H₂₀ClNO₂S
Molecular Weight:337.87
Hs Code.:

Synonyms:1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine

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Chemical Property of 1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine

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Technology Process of 1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine

There total 3 articles about 1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1100768-38-4
1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethanone

: 1100768-39-5
1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine

Guidance literature:: With ammonium acetate; sodium cyanoborohydride; In methanol; for 6h; Heating / reflux;

Reference yield:

: 870777-29-0
(5-acetyl-2-fluorophenyl)boronic acid

: 1100768-39-5
1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 3 h / Heating / reflux

2.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 - 10 °C

2.2: 1 h / 20 °C

3.1: ammonium acetate; sodium cyanoborohydride / methanol / 6 h / Heating / reflux

With ammonium acetate; sodium hydride; sodium cyanoborohydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1100768-39-5
1-[3-(5-chloro-thiophen-2-yl)-4-(tetrahydro-pyran-4-yloxy)-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 - 10 °C

1.2: 1 h / 20 °C

2.1: ammonium acetate; sodium cyanoborohydride / methanol / 6 h / Heating / reflux

With ammonium acetate; sodium hydride; sodium cyanoborohydride; In methanol; dimethyl sulfoxide;