2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

Base Information

Chemical Name:2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester
CAS No.:243462-83-1
Molecular Formula:C₁₈H₂₀BrNO₄S₂
Molecular Weight:458.397
Hs Code.:

Synonyms:2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

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Chemical Property of 2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

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Technology Process of 2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

There total 2 articles about 2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 243462-82-0
5-amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

: 243462-83-1
2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

Guidance literature:: With bromine; In dichloromethane; at -40 ℃; for 0.75h;
DOI:10.1002/jhet.5570360330

Reference yield:

: 227312-14-3
5-amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

: 243462-83-1
2-bromo-5-(1,1-dimethylethoxycarbonyl)amino-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / Heating

2: 92 percent / Br₂ / CH₂Cl₂ / 0.75 h / -40 °C

With dmap; bromine; triethylamine; In dichloromethane;
DOI:10.1002/jhet.5570360330