(E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene

Base Information

• Chemical Name: (E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene
• CAS No.: 566898-70-2
• Molecular Formula: C₁₈H₁₇NO₄S₂
• Molecular Weight: 375.469
• Mol file: 566898-70-2.mol

Synonyms:(E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene

Chemical Property of (E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene

There total 2 articles about (E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

m-tolylmagnesium bromide (28987-79-3) + (1E,3E)-1-(4-(methylthio)-2-nitro-3-(phenylsulfonyl)buta-1,3-dien-1-yl)pyrrolidine (566898-65-5) → (E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene (566898-70-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo034264q

Reference yield:

3-nitro-4-(phenylsulfonyl)thiophene → (E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene (566898-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AgNO₃ / ethanol / 0.25 h / 40 °C

1.2: ethanol / 15 h / 40 °C

1.3: 87 percent / ethanol / 4 h / 20 °C

2.1: 95 percent / tetrahydrofuran / 0 - 20 °C

With silver nitrate; In tetrahydrofuran; ethanol;

DOI:10.1021/jo034264q

Reference yield: 98.0%

(E,E)-1-(3-methylphenyl)-4-methylthio-2-nitro-3-phenylsulfonyl-1,3-butadiene (566898-70-2) → (E,E)-1-(3-methylphenyl)-4-methylsulfonyl-2-nitro-3-phenylsulfonyl-1,3-butadiene (566898-79-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jo034264q

upstream raw materials:

m-tolylmagnesium bromide

(1E,3E)-1-(4-(methylthio)-2-nitro-3-(phenylsulfonyl)buta-1,3-dien-1-yl)pyrrolidine

Downstream raw materials:

(E,E)-1-(3-methylphenyl)-4-methylsulfonyl-2-nitro-3-phenylsulfonyl-1,3-butadiene