1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Base Information

Chemical Name:1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone
CAS No.:1333471-88-7
Molecular Formula:C₂₃H₂₄BrN₃O₆
Molecular Weight:518.364
Hs Code.:

Synonyms:1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

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Chemical Property of 1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

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Technology Process of 1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

There total 9 articles about 1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1333473-19-0
1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanol

: 1333471-88-7
1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.833333h; Inert atmosphere;

Reference yield:

: 1333473-18-9
4-(4-(2-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-(1-ethoxyethoxy)-1-methoxyethyl)phenyl)morpholine

: 1333471-88-7
1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / methanol / 22.5 h / 20 - 40 °C

2: Dess-Martin periodane / dichloromethane / 0.83 h / 20 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; Dess-Martin periodane; In methanol; dichloromethane;

Reference yield:

: (RS)-methoxy-(4-morpholin-4-yl-phenyl)-acetic acid

: 1333471-88-7
1-(5-(4-bromo-3,5-dimethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.83 h / Inert atmosphere; Cooling with ice

1.2: 16 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene; hexanes / 1.08 h / -78 °C

2.2: 0.5 h / 20 °C

3.1: zinc(II) iodide / diethyl ether / 15.5 h / 20 °C

4.1: pyridinium p-toluenesulfonate / dichloromethane / 40 h / 20 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 16 h / 60 - 75 °C / Inert atmosphere

6.1: dmap; triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere; Cooling with ice

6.2: 7 h / 120 °C / Inert atmosphere

7.1: pyridinium p-toluenesulfonate / methanol / 22.5 h / 20 - 40 °C

8.1: Dess-Martin periodane / dichloromethane / 0.83 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; hydroxylamine hydrochloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; zinc(II) iodide; isobutyl chloroformate; In methanol; hexanes; diethyl ether; dichloromethane; toluene;