methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

Base Information

Chemical Name:methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate
CAS No.:1404555-88-9
Molecular Formula:C₃₁H₃₆FN₅O₅
Molecular Weight:577.656
Hs Code.:

methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

Synonyms:methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

There total 8 articles about methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 261951-71-7
2-(bromomethyl)-4-fluoro-1-methylbenzene

: 1404555-84-5
methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

: 1404555-88-9
methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 3h;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 853070-08-3
C₂₉H₃₃ClIN₅O₅

: 1404555-88-9
methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

3: 10% Pd/C; ammonium formate / methanol / 2 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 65 °C

With silver (I) hydrogen carbonate; 10% Pd/C; palladium diacetate; ammonium formate; potassium carbonate; triphenylphosphine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 853070-06-1
C₃₂H₃₉ClIN₅O₅

: 1404555-88-9
methyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-(5-fluoro-2-methylbenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

3: hydrogenchloride / 1,4-dioxane / 4 h / 80 °C

4: sodium hydrogencarbonate / tetrahydrofuran; water / 3 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 45 °C

6: 10% Pd/C; ammonium formate / methanol / 2 h / Reflux

7: potassium carbonate / N,N-dimethyl-formamide / 3 h / 65 °C

With hydrogenchloride; silver (I) hydrogen carbonate; 10% Pd/C; palladium diacetate; ammonium formate; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046