5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

Base Information

Chemical Name:5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester
CAS No.:173677-24-2
Molecular Formula:C₂₉H₄₀BrNO₆
Molecular Weight:578.544
Hs Code.:

Synonyms:5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

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Chemical Property of 5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

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Technology Process of 5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

There total 1 articles about 5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4509-90-4
5-bromovaleroyl chloride

: 4-[(R)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butan-1-ol; hydrochloride

: 173677-24-2
5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

Guidance literature:: In acetonitrile; 1.) 80 deg, 5.25 h, 2.) RT, overnight;
DOI:10.1021/jm950477z

Reference yield: 73.0%

: 10192-85-5
potassium acrylate

: 173677-24-2
5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

: 173677-25-3
5-Acryloyloxy-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

Guidance literature:: With 18-crown-6 ether; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 40 ℃; for 24h;
DOI:10.1021/jm950477z

Reference yield:

: 173677-24-2
5-Bromo-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

: 5-[3-(6,7,8-Trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propionyloxy]-pentanoic acid 4-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 18-crown-6 / hexamethylphosphoric acid triamide / 24 h / 40 °C

2: 56 percent / glacial acetic acid / benzene / 23 h / Heating

With 18-crown-6 ether; acetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; benzene;
DOI:10.1021/jm950477z