3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene

Base Information

• Chemical Name: 3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene
• CAS No.: 116193-76-1
• Molecular Formula: C₁₄H₁₉N₃O₈
• Molecular Weight: 357.32
• Mol file: 116193-76-1.mol

Synonyms:3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene

Chemical Property of 3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene

There total 1 articles about 3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3,5-bis<2-(2-propyl)-1,3-dioxane-5-carboxamido>nitrobenzene (116193-75-0) → 3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene (116193-76-1)

Guidance literature:

With sulfuric acid; In methanol; for 5.5h; Heating;

DOI:10.1021/jm00105a060

Reference yield: 94.0%

3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene (116193-76-1) → N-[3-Amino-5-(3-hydroxy-2-hydroxymethyl-propionylamino)-phenyl]-3-hydroxy-2-hydroxymethyl-propionamide (116193-77-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 10h; under 1551.4 Torr;

DOI:10.1021/jm00105a060

Reference yield:

3,5-bis<2-(hydroxymethyl)-3-hydroxypropionamido>nitrobenzene (116193-76-1) → (Z)-N,N'-(5-{[1-(5-acetyl-4-hydroxy-2,6-dioxo-2H-pyran-3(6H)-ylidene)ethyl]amino}-1,3-phenylene)bis[2-(hydroxymethyl)-3-hydroxypropionamide] (130437-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / H₂ / 10percent Pd/C / methanol / 10 h / 1551.4 Torr

2: 48 percent / methanol / 2 h / Heating

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00105a060

upstream raw materials:

3,5-bis<2-(2-propyl)-1,3-dioxane-5-carboxamido>nitrobenzene

Downstream raw materials:

N-[3-Amino-5-(3-hydroxy-2-hydroxymethyl-propionylamino)-phenyl]-3-hydroxy-2-hydroxymethyl-propionamide

(Z)-N,N'-(5-{[1-(5-acetyl-4-hydroxy-2,6-dioxo-2H-pyran-3(6H)-ylidene)ethyl]amino}-1,3-phenylene)bis[2-(hydroxymethyl)-3-hydroxypropionamide]