methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate

Base Information

Chemical Name:methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate
CAS No.:1093632-00-8
Molecular Formula:C₃₁H₂₆Cl₂N₂O₄
Molecular Weight:561.464
Hs Code.:

Synonyms:methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate

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Chemical Property of methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate

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Technology Process of methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate

There total 4 articles about methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5776-28-3
8-hydroxy-[2]naphthoic acid

: 1093632-00-8
methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / Reflux

2.1: pyridine / dichloromethane / 1.5 h / 0 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 48 h / Reflux

4.1: boron tribromide / dichloromethane / 4 h / 0 °C

4.2: Cooling with ice

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 48 h / 0 - 20 °C

With pyridine; thionyl chloride; di-isopropyl azodicarboxylate; boron tribromide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; toluene; 5.1: Mitsunobu reaction;

Reference yield:

: 115399-09-2
7-methoxycarbonyl-1-naphthol

: 1093632-00-8
methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1.5 h / 0 °C

2.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 48 h / Reflux

3.1: boron tribromide / dichloromethane / 4 h / 0 °C

3.2: Cooling with ice

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 48 h / 0 - 20 °C

With pyridine; di-isopropyl azodicarboxylate; boron tribromide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; toluene; 4.1: Mitsunobu reaction;

Reference yield:

: 1093631-98-1
methyl 8-{[(trifluoromethyl)sulfonyl]oxy}-2-naphthalene carboxylate

: 1093632-00-8
methyl 8-{[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]amino}-2-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 48 h / Reflux

2.1: boron tribromide / dichloromethane / 4 h / 0 °C

2.2: Cooling with ice

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 48 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; boron tribromide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; toluene; 3.1: Mitsunobu reaction;