2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone

Base Information

• Chemical Name: 2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone
• CAS No.: 104960-62-5
• Molecular Formula: C₁₇H₁₀F₃N₃OS
• Molecular Weight: 361.347
• Mol file: 104960-62-5.mol

Synonyms:2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone

Chemical Property of 2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone

There total 8 articles about 2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-[2-(3-Cyano-6-phenyl-4-trifluoromethyl-pyridin-2-ylsulfanyl)-acetyl]-acetamide → 2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone (104960-62-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 1.5h; Heating;

DOI:10.1007/BF02291809

Reference yield: 69.0%

N-acetyl-2-chloroacetamide (17368-73-9) + 2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (104960-49-8) → 2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone (104960-62-5)

Guidance literature:

With potassium hydroxide; In ethanol; 50 deg C, 30 min, reflux, 1.5 h;

DOI:10.1007/BF02291809

Reference yield: 50.0%

6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone (104960-61-4) → 2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone (104960-62-5)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 90 - 95 ℃; for 1h;

upstream raw materials:

6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone

N-acetyl-2-chloroacetamide

2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

1-Phenyl-4,4,4-trifluorobutane-1,3-dione