(5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione

Base Information

Chemical Name:(5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione
CAS No.:130508-79-1
Molecular Formula:C₂₂H₂₂N₂O₆
Molecular Weight:410.426
Hs Code.:

Synonyms:(5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione

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Chemical Property of (5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione

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Technology Process of (5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione

There total 8 articles about (5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 141782-37-8
(2'R,3'R,5Z)-5-(4'-benzyloxy-2',3'-dihydroxybutylidene)-3-(p-methoxybenzyl)hydantoin

: 130508-79-1
(5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione

: 130607-49-7
5'-O-benzyl-2'-deoxy-3-N-(p-methoxybenzyl)-3'-oxohydantocidin

Guidance literature:: (2'R,3'R,5Z)-5-(4'-benzyloxy-2',3'-dihydroxybutylidene)-3-(p-methoxybenzyl)hydantoin; With triethylamine; In 1,2-dichloro-ethane; for 6h; Heating;

With 3 A molecular sieve; sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 0.25h; Further stages.;
DOI:10.1002/(SICI)1099-0690(200005)2000:9<1831::AID-EJOC1831>3.0.CO;2-S

Reference yield:

: 129744-26-9
N-acetyl N-methoxybenzylhydantoin

: 130508-79-1
(5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / tBuOK / tetrahydrofuran / 0 - 20 °C

2.1: 75 percent / ethylene glycol; methanol; TsOH*H₂O / CH₂Cl₂ / 48 h / 20 °C

3.1: Et₃N / 1,2-dichloro-ethane / 6 h / Heating

3.2: 27 percent / molecular sieves 3 Angstroem; PCC; NaOAc / CH₂Cl₂ / 0.25 h / 20 °C

With methanol; potassium tert-butylate; toluene-4-sulfonic acid; ethylene glycol; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1.1: Condensation / 2.1: Decomposition / 3.1: Cyclization / 3.2: Oxidation;
DOI:10.1002/(SICI)1099-0690(200005)2000:9<1831::AID-EJOC1831>3.0.CO;2-S

Reference yield:

: 81801-09-4
4-O-benzyl-2,3-O-isopropylidene-D-threose

: 130508-79-1
(5R,7R)-7-Benzyloxymethyl-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4,8-trione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / tBuOK / tetrahydrofuran / 0 - 20 °C

2.1: 75 percent / ethylene glycol; methanol; TsOH*H₂O / CH₂Cl₂ / 48 h / 20 °C

3.1: Et₃N / 1,2-dichloro-ethane / 6 h / Heating

3.2: 27 percent / molecular sieves 3 Angstroem; PCC; NaOAc / CH₂Cl₂ / 0.25 h / 20 °C

With methanol; potassium tert-butylate; toluene-4-sulfonic acid; ethylene glycol; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1.1: Condensation / 2.1: Decomposition / 3.1: Cyclization / 3.2: Oxidation;
DOI:10.1002/(SICI)1099-0690(200005)2000:9<1831::AID-EJOC1831>3.0.CO;2-S