1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride

Base Information

• Chemical Name: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride
• CAS No.: 1020717-77-4
• Molecular Formula: C₁₀H₆ClF₂N₃O
• Molecular Weight: 257.627
• Mol file: 1020717-77-4.mol

Synonyms:1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride

Chemical Property of 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride

There total 6 articles about 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-difluorobenzyl chloride (697-73-4) → 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride (1020717-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / water / 70 °C / Inert atmosphere

2: ascorbic acid; copper diacetate / water; tert-butyl alcohol / 20 °C / Sonication

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 7 h / 0 - 20 °C / Cooling with ice

With sodium azide; oxalyl dichloride; copper diacetate; N,N-dimethyl-formamide; ascorbic acid; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jacs.7b03131

Reference yield:

CGP 47292 (166196-11-8) → 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride (1020717-77-4)

Guidance literature:

With thionyl chloride; at 20 ℃; Reflux;

Reference yield:

2-(azidomethyl)-1,3-difluorobenzene (106308-60-5) → 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride (1020717-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; tert-butyl alcohol / 24 h / 75 - 80 °C

2.1: sodium hydroxide; water / 20 °C

2.2: 25 - 30 °C / pH 2 - 3

3.1: thionyl chloride / 3 h / 80 °C

With thionyl chloride; water; sodium hydroxide; In water; tert-butyl alcohol;

upstream raw materials:

CGP 47292

2,6-Difluorobenzyl bromide

2-(azidomethyl)-1,3-difluorobenzene

methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate

Downstream raw materials:

rufinamide