3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol

Base Information

Chemical Name:3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol
CAS No.:425641-99-2
Molecular Formula:C₃₇H₄₂N₂O₄Si
Molecular Weight:606.837
Hs Code.:

3,4-bis-benzyloxy-1-(<i>tert</i>-butyl-diphenyl-silanyloxy)-4-(1<i>H</i>-imidazol-4-yl)-butan-2-ol

Synonyms:3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol

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Chemical Property of 3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol

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Technology Process of 3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol

There total 1 articles about 3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: (2S,3R,4S)-3,4-Bis-benzyloxy-4-(1H-imidazol-4-yl)-butane-1,2-diol

: 425641-99-2
3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol

Guidance literature:: With 1H-imidazole; dmap; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1002/1099-0690(200202)2002:4<702::AID-EJOC702>3.0.CO;2-Y

Reference yield: 71.0%

: 425641-99-2
3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol

: 425642-00-8
6,7-bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole

Guidance literature:: With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -25 - 20 ℃; for 1.5h;
DOI:10.1002/1099-0690(200202)2002:4<702::AID-EJOC702>3.0.CO;2-Y

Reference yield:

: 425641-99-2
3,4-bis-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(1H-imidazol-4-yl)-butan-2-ol

: 425642-01-9
(6,7-bis-benzyloxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / Tf₂O; pyridine / CH₂Cl₂ / 1.5 h / -25 - 20 °C

2: 95 percent / TBAF / tetrahydrofuran / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; 1: intramolecular Walden inversion;
DOI:10.1002/1099-0690(200202)2002:4<702::AID-EJOC702>3.0.CO;2-Y