3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester

Base Information

Chemical Name:3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester
CAS No.:1268161-79-0
Molecular Formula:C₃₉H₄₇NO₇S
Molecular Weight:673.871
Hs Code.:

Synonyms:3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester

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Chemical Property of 3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester

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Technology Process of 3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester

There total 1 articles about 3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: propanoic acid (1R,2S)-2-(N-benzyl-1-(3,5-dimethylphenyl)methylsulfonamido)-1-phenylpropyl ester

: 128461-65-4
3-(p-methoxybenzyloxy)propanal

: 1268161-79-0
3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: propanoic acid (1R,2S)-2-(N-benzyl-1-(3,5-dimethylphenyl)methylsulfonamido)-1-phenylpropyl ester; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; at -78 ℃; for 2.33333h;

3-(p-methoxybenzyloxy)propanal; In dichloromethane; at -78 - 0 ℃;

With dihydrogen peroxide; In methanol; dichloromethane; water; at 0 - 20 ℃; pH=7; diastereoselective reaction; aq. phosphate buffer;
DOI:10.1002/anie.201005226

Reference yield: 78.0%

: 1268161-79-0
3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 1268161-81-4
5-(4-methoxy-benzyloxy)-3-(R)-(triethylsilyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethyl-benzolsulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 1.16667h;
DOI:10.1002/anie.201005226

Reference yield:

: 1268161-79-0
3-(R)-hydroxy-5-(4-methoxy-benzyloxy)-2-(R)-methyl-pentanoic acid 2-[benzyl-(2,4,6-trimethylbenzolsulfonyl)-amino]-1-phenyl-propyl ester

: 1268161-83-6
(3R,4S,5R)-7-(4-methoxybenzyloxy)-4-methyl-5-(triethylsilyloxy)-hept-1-ene-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1.17 h / -78 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 6 h / -78 - -50 °C

2.2: 20 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

4.1: tetrahydrofuran / 1.5 h / -78 °C

4.2: -78 - 20 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/anie.201005226