Carbamic acid, (4-acetyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (4-acetyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 762271-84-1
• Molecular Formula: C₁₀H₁₄N₂O₃S
• Molecular Weight: 242.299
• Hs Code.: 2934100090
• Mol file: 762271-84-1.mol

Synonyms:(4-Acetylthiazol-2-yl)carbamicacid tert-butyl ester

Chemical Property of Carbamic acid, (4-acetyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 96.53000
• LogP: 2.76570

Purity/Quality:

tert-butyl4-acetylthiazol-2-ylcarbamate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (4-acetyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)

There total 4 articles about Carbamic acid, (4-acetyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-bromobutane-2,3-dione (5308-51-0) + tert-butyl carbamothioylcarbamate (268551-65-1) → (4-Acetyl-thiazol-2-yl)-carbamic acid tert-butyl ester (762271-84-1)

Guidance literature:

1-bromobutane-2,3-dione; tert-butyl carbamothioylcarbamate; In ethanol; at 20 ℃; for 2h;

With sodium carbonate; In ethanol; for 0.666667h;

Reference yield: 86.0%

tert-butyl N-[4-[methoxy(methyl)carbamoyl]-1,3-thiazol-2-yl]carbamate (762271-82-9) + methyllithium (917-54-4) → (4-Acetyl-thiazol-2-yl)-carbamic acid tert-butyl ester (762271-84-1)

Guidance literature:

tert-butyl N-[4-[methoxy(methyl)carbamoyl]-1,3-thiazol-2-yl]carbamate; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 7h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (4-Acetyl-thiazol-2-yl)-carbamic acid tert-butyl ester (762271-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2.1: ethanol / 2 h / 20 °C

2.2: 0.67 h

With sodium hydride; In tetrahydrofuran; ethanol;

upstream raw materials:

tert-butyl N-[4-[methoxy(methyl)carbamoyl]-1,3-thiazol-2-yl]carbamate

methyllithium

di-tert-butyl dicarbonate

1-bromobutane-2,3-dione

Downstream raw materials:

tert-butyl (4-(2-hydroxypropan-2-yl)thiazol-2-yl)carbamate

1-(2-amino-1,3-thiazol-4-yl)ethanone

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