Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:181961-12-6
Molecular Formula:C₂₂H₃₁ClN₂O₅
Molecular Weight:438.952
Hs Code.:

Synonyms:Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 7 articles about Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22020-87-7
5-nitro-2-pentanone

: 181961-12-6
Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / Br₂ / methanol / 2 h / 25 - 30 °C

2: 89 percent / benzene / 48 h / Ambient temperature

3: 13.5 g / 1percent NaOH / CH₂Cl₂

4: 84 percent / CH₂Cl₂ / 8 h / Heating

5: 59 percent / KF/Al₂O₃ / tetrahydrofuran / Ambient temperature

6: 67 percent / NaBH₄ / ethanol

7: pyridine

With pyridine; aluminum oxide; potassium fluoride; sodium hydroxide; sodium tetrahydroborate; bromine; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1016/0040-4020(96)00623-0

Reference yield:

: 166179-38-0
1-(bromo)-5-(nitro)-pentane-2-one

: 181961-12-6
Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / benzene / 48 h / Ambient temperature

2: 13.5 g / 1percent NaOH / CH₂Cl₂

3: 84 percent / CH₂Cl₂ / 8 h / Heating

4: 59 percent / KF/Al₂O₃ / tetrahydrofuran / Ambient temperature

5: 67 percent / NaBH₄ / ethanol

6: pyridine

With pyridine; aluminum oxide; potassium fluoride; sodium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; ethanol; dichloromethane; benzene;
DOI:10.1016/0040-4020(96)00623-0

Reference yield:

: (+/-)-1α-nitro-2β-<3-(6-chloropyridyl)>-cyclohexane-4-one

: 181961-12-6
Carbonic acid (1S,3R,4S)-3-(6-chloro-pyridin-3-yl)-4-nitro-cyclohexyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / NaBH₄ / ethanol

2: pyridine

With pyridine; sodium tetrahydroborate; In ethanol;
DOI:10.1016/0040-4020(96)00623-0