6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline

Base Information

• Chemical Name: 6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline
• CAS No.: 1395726-77-8
• Molecular Formula: C₃₃H₃₅NO₂
• Molecular Weight: 477.646
• Mol file: 1395726-77-8.mol

Synonyms:6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline

Chemical Property of 6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline

There total 1 articles about 6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-bromo-4,5-dimethoxybenzaldehyde (5392-10-9) + 1,4-bis(4-tert-butylphenyl)buta-1,3-diyne (183210-84-6) → 6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline (1395726-77-8)

Guidance literature:

2-bromo-4,5-dimethoxybenzaldehyde; With tert-butylamine; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere;

1,4-bis(4-tert-butylphenyl)buta-1,3-diyne; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; lithium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 26h; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.067

Reference yield: 94.0%

6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline (1395726-77-8) → 7-iodo-2,3-dimethoxy-10-tert-butyl-8-(4-tert-butylphenyl) benzo[a]phenanthridine (1395728-78-5)

Guidance literature:

With Iodine monochloride; In dichloromethane; acetonitrile; at 0 ℃; for 0.416667h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.067

Reference yield: 67.0%

6,7-dimethoxy-4-(4-tert-butylphenyl)-3-[2-(4-tert-butylphenyl)ethynyl]isoquinoline (1395726-77-8) → 2,3-dimethoxy-10-tert-butyl-8-(4-tert-butylphenyl)benzo[a]phenanthridine (1395727-90-8)

Guidance literature:

With silver hexafluoroantimonate; (triphenylphosphine)gold(I) chloride; In toluene; at 120 ℃; for 8h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.067

upstream raw materials:

2-bromo-4,5-dimethoxybenzaldehyde

1,4-bis(4-tert-butylphenyl)buta-1,3-diyne

Downstream raw materials:

2,3-dimethoxy-10-tert-butyl-8-(4-tert-butylphenyl)benzo[a]phenanthridine

7-iodo-2,3-dimethoxy-10-tert-butyl-8-(4-tert-butylphenyl) benzo[a]phenanthridine