N⁴-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Base Information

• Chemical Name: N⁴-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
• CAS No.: 127117-79-7
• Molecular Formula: C₃₆H₄₄N₄O₆
• Molecular Weight: 628.769
• Mol file: 127117-79-7.mol

Synonyms:N⁴-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Chemical Property of N⁴-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N⁴-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

There total 1 articles about N⁴-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1,6-Hexanediamine (124-09-4) + 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → N4-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (127117-79-7)

Guidance literature:

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In isopropyl alcohol; at 60 ℃;

DOI:10.1080/07328319808004233

Reference yield: 90.0%

trifluoroacetic acid-methyl ester (431-47-0) + N4-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (127117-79-7) → N-[6-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-ylamino)-hexyl]-2,2,2-trifluoro-acetamide

Guidance literature:

In dichloromethane; for 1h; Ambient temperature;

DOI:10.1080/07328319808004233

Reference yield: 62.0%

3-nitro-4-{[(trifluoroacetyl)amino]methyl}benzoic acid (130029-56-0) + N4-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (127117-79-7) → 4-N-{6-[3-nitro-4-(trifluoroacetamidomethyl)]benzamidohexyl}-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (912558-44-2)

Guidance literature:

3-nitro-4-{[(trifluoroacetyl)amino]methyl}benzoic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetone; for 1h;

N⁴-(6-aminohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine; With TEA; In acetone; for 2h;

DOI:10.1080/15257770500230509

upstream raw materials:

1,6-Hexanediamine

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-N⁴-[6-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)hexyl]-2'-deoxycytidine

4-N-{6-[3-nitro-4-(trifluoroacetamidomethyl)]benzamidohexyl}-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine