C₁₅H₁₁N₃O

Base Information

• Chemical Name: C₁₅H₁₁N₃O
• CAS No.: 1449379-67-2
• Molecular Formula: C₁₅H₁₁N₃O
• Molecular Weight: 249.272
• Mol file: 1449379-67-2.mol

Synonyms:C₁₅H₁₁N₃O

Chemical Property of C₁₅H₁₁N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁N₃O

There total 5 articles about C₁₅H₁₁N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-[2-(2-aminophenyl)ethynyl]benzenemethanol (197729-98-9) → C15H11N3O (1449379-67-2)

Guidance literature:

α-[2-(2-aminophenyl)ethynyl]benzenemethanol; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.75h; Inert atmosphere;

With sodium azide; In water; at 0 ℃; for 0.75h;

DOI:10.1021/ol4019634

Reference yield:

1-phenyl-3-trimethylsilylprop-2-yn-1-ol (89530-34-7) → C15H11N3O (1449379-67-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 20 °C

2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.08 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: sulfuric acid; sodium nitrite / water / 0.75 h / 0 °C / Inert atmosphere

3.2: 0.75 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; potassium carbonate; triethylamine; sodium nitrite; In methanol; water; 2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling / 3.1: |Sandmeyer Reaction / 3.2: |Sandmeyer Reaction;

DOI:10.1021/ol4019634

Reference yield:

1-Phenyl-2-propyn-1-ol (4187-87-5) → C15H11N3O (1449379-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 0.08 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sulfuric acid; sodium nitrite / water / 0.75 h / 0 °C / Inert atmosphere

2.2: 0.75 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; triethylamine; sodium nitrite; In water; 1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling / 2.1: |Sandmeyer Reaction / 2.2: |Sandmeyer Reaction;

DOI:10.1021/ol4019634

upstream raw materials:

1-phenyl-3-trimethylsilylprop-2-yn-1-ol

1-Phenyl-2-propyn-1-ol

α-[2-(2-aminophenyl)ethynyl]benzenemethanol

benzaldehyde

Downstream raw materials:

(2Z)-2-(phenylmethylidene)-2,3-dihydro-1H-indol-3-one

3-(2-azidophenyl)-1-phenylprop-2-yn-1-yl acetate

3-(2-azidophenyl)-1-phenylprop-2-yn-1-yl methyl carbonate

(2-phenylquinolin-4-yl) methyl carbonate