methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate

Base Information

Chemical Name:methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate
CAS No.:259868-53-6
Molecular Formula:C₃₂H₃₉NO₆
Molecular Weight:533.665
Hs Code.:

Synonyms:methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate

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Chemical Property of methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate

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Technology Process of methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate

There total 4 articles about methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 259868-85-4
methyl (R)-3-[1-(benzyloxycarbonyl)pyrrolidin-2-yl]acrylate

: 259868-53-6
methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 1 h / 20 °C / 750.06 Torr

2: 239 mg / K₂CO₃; KI / acetone / 48 h / 20 °C

With hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; acetone;
DOI:10.1016/j.ejmech.2006.01.019

Reference yield:

: 182210-00-0
methyl (2R)-(benzyloxycarbonyl)pyrrolidine-2-carboxylate

: 259868-53-6
methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: DIBAH / hexane; toluene / 1 h / -60 °C

2: 1.48 g / LiCl; DIPEA / acetonitrile / 16 h

3: H₂ / Pd/C / methanol / 1 h / 20 °C / 750.06 Torr

4: 239 mg / K₂CO₃; KI / acetone / 48 h / 20 °C

With hydrogen; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; lithium chloride; palladium on activated charcoal; In methanol; hexane; acetone; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2006.01.019

Reference yield:

: 50463-82-6,71461-30-8,105706-84-1,143393-11-7
(2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate

: 259868-53-6
methyl (R)-3-(1-{2-[tris-(4-methoxyphenyl)methoxy]ethyl}pyrrolidin-2-yl)propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.48 g / LiCl; DIPEA / acetonitrile / 16 h

2: H₂ / Pd/C / methanol / 1 h / 20 °C / 750.06 Torr

3: 239 mg / K₂CO₃; KI / acetone / 48 h / 20 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; lithium chloride; palladium on activated charcoal; In methanol; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2006.01.019