5'-O-(4,4'-dimethoxytrityl)-N⁴-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-N⁴-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine
• CAS No.: 776297-95-1
• Molecular Formula: C₅₈H₇₉N₇O₁₅
• Molecular Weight: 1114.3
• Mol file: 776297-95-1.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-N⁴-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-N⁴-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-N⁴-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine

There total 7 articles about 5'-O-(4,4'-dimethoxytrityl)-N⁴-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[bis[2-(benzyloxycarbonylamino)ethyl]amino]acetic acid tert-butyl ester (174700-73-3) → 5'-O-(4,4'-dimethoxytrityl)-N4-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine (776297-95-1)

Guidance literature:

Multi-step reaction with 5 steps

1: formic acid / Pd/C / methanol / 2 h / 18 °C

2: 1.50 g / i-Pr₂NEt / acetonitrile / 18 h / 0 - 18 °C

3: 46 percent / TFA / 2 h / 18 °C

4: N-methylmorpholine / tetrahydrofuran / 0.33 h / -15 °C

5: 147 mg / tetrahydrofuran / 18 h / 4 °C

With 4-methyl-morpholine; formic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1055/s-2004-829143

Reference yield:

[bis[2-bis(ethoxycarbonylmethylamino)ethyl]amino]acetic acid (217653-57-1) → 5'-O-(4,4'-dimethoxytrityl)-N4-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine (776297-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / tetrahydrofuran / 0.33 h / -15 °C

2: 147 mg / tetrahydrofuran / 18 h / 4 °C

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.1055/s-2004-829143

Reference yield:

[bis-(2-amino-ethyl)-amino]-acetic acid tert-butyl ester (521972-74-7) → 5'-O-(4,4'-dimethoxytrityl)-N4-[trans-4-(N,N-bis{2-[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine (776297-95-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.50 g / i-Pr₂NEt / acetonitrile / 18 h / 0 - 18 °C

2: 46 percent / TFA / 2 h / 18 °C

3: N-methylmorpholine / tetrahydrofuran / 0.33 h / -15 °C

4: 147 mg / tetrahydrofuran / 18 h / 4 °C

With 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;

DOI:10.1055/s-2004-829143

upstream raw materials:

N⁴-(trans-4-aminocyclohexyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

trans-1,4-cyclohexyldiamine

[bis[2-bis(ethoxycarbonylmethylamino)ethyl]amino]acetic acid

[bis-(2-amino-ethyl)-amino]-acetic acid tert-butyl ester