2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester
CAS No.:853750-27-3
Molecular Formula:C₃₁H₄₀O₁₀
Molecular Weight:572.653
Hs Code.:

2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

Synonyms:2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

There total 3 articles about 2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 853750-25-1
(2S,3S)-2-[(R)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-3-(3,4-methylenedioxybenzoyl)tetramethylene dipivaloate

: 853750-27-3
2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1039/b501151e

Reference yield:

: (2R,3S)-3-[(R)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-2-[(hydroxy)(3,4-methylenedioxyphenyl)methyl]-4-butanolide

: 853750-27-3
2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LiBH₄ / tetrahydrofuran / 24 h / 0 °C

2: 1.77 g / pyridine / 0.5 h / 20 °C

3: 94 percent / PCC; 4 Angstroem molecular sieves / CH₂Cl₂ / 16 h / 20 °C

4: 87 percent / tetrabutylammonium fluoride; AcOH / tetrahydrofuran / 16 h / 20 °C

With pyridine; lithium borohydride; 4 A molecular sieve; tetrabutyl ammonium fluoride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b501151e

Reference yield:

: (1R,2S,3S,4R)-1-Benzo[1,3]dioxol-5-yl-4-(3,4-dimethoxy-phenyl)-2,3-bis-hydroxymethyl-4-triisopropylsilanyloxy-butan-1-ol

: 853750-27-3
2,2-Dimethyl-propionic acid (3S,4S,5R)-2-benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-(2,2-dimethyl-propionyloxymethyl)-2-hydroxy-tetrahydro-furan-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.77 g / pyridine / 0.5 h / 20 °C

2: 94 percent / PCC; 4 Angstroem molecular sieves / CH₂Cl₂ / 16 h / 20 °C

3: 87 percent / tetrabutylammonium fluoride; AcOH / tetrahydrofuran / 16 h / 20 °C

With pyridine; 4 A molecular sieve; tetrabutyl ammonium fluoride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b501151e