1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

Base Information

Chemical Name:1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea
CAS No.:1344738-00-6
Molecular Formula:C₃₄H₃₃N₇O₃S₂
Molecular Weight:651.813
Hs Code.:

Synonyms:1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

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Chemical Property of 1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

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Technology Process of 1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

There total 13 articles about 1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylthio)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

: 1344738-00-6
1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

Guidance literature:: With water; dihydrogen peroxide; In 1,1,1,3',3',3'-hexafluoro-propanol; at 20 ℃; for 0.5h;
DOI:10.1021/jm200677b

Reference yield:

: C₂₇H₂₃N₃O₄S₂

: 1344738-00-6
1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4: water; dihydrogen peroxide / 1,1,1,3',3',3'-hexafluoro-propanol / 0.5 h / 20 °C

With ammonia; water; dihydrogen peroxide; boron tribromide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; 1,1,1,3',3',3'-hexafluoro-propanol;
DOI:10.1021/jm200677b

Reference yield:

: 1-{1-[3-(benzyloxy)phenyl]-3-tert-butyl-1H-pyrazol-5-yl}-3-[2-({3-[2-(methylthio)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

: 1344738-00-6
1-[3-tert-butyl-1-(3-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[2-(methylsulfinyl)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: water; dihydrogen peroxide / 1,1,1,3',3',3'-hexafluoro-propanol / 0.5 h / 20 °C

With water; dihydrogen peroxide; boron tribromide; In dichloromethane; 1,1,1,3',3',3'-hexafluoro-propanol;
DOI:10.1021/jm200677b