4-(4-Chloro-2-methoxyphenyl)pyridin-2(1H)-one

Base Information

• Chemical Name: 4-(4-Chloro-2-methoxyphenyl)pyridin-2(1H)-one
• CAS No.: 1173157-22-6
• Molecular Formula: C₁₂H₁₀ClNO₂
• Molecular Weight: 235.67
• DSSTox Substance ID: DTXSID90683003
• Wikidata: Q82607625

Synonyms:1173157-22-6;4-(4-Chloro-2-methoxyphenyl)pyridin-2(1H)-one;4-(4-CHLORO-2-METHOXYPHENYL)-2-HYDROXYPYRIDINE;SCHEMBL3477513;DTXSID90683003;ACMZBASPCQBHMQ-UHFFFAOYSA-N;MFCD18312328

Chemical Property of 4-(4-Chloro-2-methoxyphenyl)pyridin-2(1H)-one

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 235.0400063
• Heavy Atom Count: 16
• Complexity: 338

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)Cl)C2=CC(=O)NC=C2

Technology Process of 4-(4-Chloro-2-methoxyphenyl)pyridin-2(1H)-one

There total 1 articles about 4-(4-Chloro-2-methoxyphenyl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(4-chloro-2-methoxyphenyl)pyridine 1-oxide (1173157-19-1) → 4-(4-chloro-2-methoxyphenyl)pyridin-2(1H)-one (1173157-22-6)

Guidance literature:

4-(4-chloro-2-methoxyphenyl)pyridine 1-oxide; With acetic anhydride; for 3h; Reflux;

With water; In methanol; for 1h; Reflux;

Reference yield: 54.0%

4-(4-chloro-2-methoxyphenyl)pyridin-2(1H)-one (1173157-22-6) + tert-butyl 7-bromo-9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1173155-46-8) → tert-butyl 7-(4-(4-chloro-2-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1173157-73-7)

Guidance literature:

With copper(l) iodide; 8-quinolinol; caesium carbonate; In dimethyl sulfoxide; at 135 ℃; for 18h; Inert atmosphere;

Reference yield: 44.0%

4-(4-chloro-2-methoxyphenyl)pyridin-2(1H)-one (1173157-22-6) + tert-butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (1173155-31-1) → tert-butyl 7-(4-(4-chloro-2-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (1173157-25-9)

Guidance literature:

With copper(l) iodide; 8-quinolinol; caesium carbonate; In dimethyl sulfoxide; at 135 ℃; Inert atmosphere;

upstream raw materials:

4-(4-chloro-2-methoxyphenyl)pyridine 1-oxide

Downstream raw materials:

tert-butyl 7-(4-(4-chloro-2-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

tert-butyl 7-(4-(4-chloro-2-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

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