(2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)

Base Information

Chemical Name:(2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)
CAS No.:1350538-48-5
Molecular Formula:C₂₈H₃₈N₆O₁₀S₂
Molecular Weight:682.776
Hs Code.:

Synonyms:(2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)

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Chemical Property of (2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)

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Technology Process of (2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)

There total 5 articles about (2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 199783-36-3
(S)-3-methyl-2-(2-nitrophenylsulfonamido)butanoic acid

: 1350538-48-5
(2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 18h;
DOI:10.3987/COM-11-12249

Reference yield:

: 32044-22-7,39961-95-0
trans-1,2-(R,R)-diammoniumcyclohexane tartrate

: 1350538-48-5
(2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; sodium hydroxide / dichloromethane / 0.17 h / 0 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 18 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.3987/COM-11-12249

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1350538-48-5
(2S,2S')-N,N'-((1R,2R)-cyclohexan-1,2-diyl)bis(3-methyl-2-(2-nitrophenylsulfonamido)butanamide)

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 17 h / 60 - 70 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 18 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.3987/COM-11-12249