(R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

Base Information

Chemical Name:(R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one
CAS No.:1616684-84-4
Molecular Formula:C₂₅H₂₉ClN₄O
Molecular Weight:436.984
Hs Code.:

Synonyms:(R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

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Chemical Property of (R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

Chemical Property:

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Technology Process of (R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

There total 9 articles about (R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1616684-83-3
(R)-4-amino-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

: 1616684-84-4
(R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

Guidance literature:: In phenol; at 140 ℃; for 5h;
DOI:10.1016/j.bmc.2014.05.024

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 1616684-84-4
(R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 0 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / 1551.49 Torr

3.1: lithium hydroxide / water; tetrahydrofuran / 30 h / 20 °C

4.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / -15 °C

4.2: 2.25 h / -15 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane

6.1: phenol / 5 h / 140 °C

With 4-methyl-morpholine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; phenol;
DOI:10.1016/j.bmc.2014.05.024

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1616684-84-4
(R)-4-(7-chloroquinolin-4-ylamino)-1-(4-methylpiperazin-1-yl)-5-phenylpentan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran; cyclohexane / 3.75 h / -80 - -69 °C

3.1: dichloromethane / 0 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / 1551.49 Torr

5.1: lithium hydroxide / water; tetrahydrofuran / 30 h / 20 °C

6.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / -15 °C

6.2: 2.25 h / -15 - 20 °C

7.1: hydrogenchloride / 1,4-dioxane

8.1: phenol / 5 h / 140 °C

With 4-methyl-morpholine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; triethylamine; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; phenol;
DOI:10.1016/j.bmc.2014.05.024