4-(Benzyloxy)-1H-indole-3-ethanamine

Base Information

Chemical Name:4-(Benzyloxy)-1H-indole-3-ethanamine
CAS No.:109249-04-9
Molecular Formula:C₁₇H₁₈N₂O
Molecular Weight:266.343
Hs Code.:
European Community (EC) Number:861-315-4
Nikkaji Number:J1.648.243I

Synonyms:4-(Benzyloxy)-1H-indole-3-ethanamine;2-(4-phenylmethoxy-1H-indol-3-yl)ethanamine;109249-04-9;SCHEMBL23805211;EN300-1275684;2-[4-(benzyloxy)-1H-indol-3-yl]ethan-1-amine

Suppliers and Price of 4-(Benzyloxy)-1H-indole-3-ethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(Benzyloxy)-1H-indole-3-ethanamine

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:266.141913202
Heavy Atom Count:20
Complexity:291

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=CC=CC3=C2C(=CN3)CCN

Technology Process of 4-(Benzyloxy)-1H-indole-3-ethanamine

There total 8 articles about 4-(Benzyloxy)-1H-indole-3-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1464-11-5
4-benzyloxyindole-3-acetonitrile

: 109249-04-9
2-(4-(benzyloxy)-1H-indol-3-yl)ethanamine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 1h; Heating;

Reference yield:

: C₁₇H₁₄N₂O₃

: 109249-04-9
2-(4-(benzyloxy)-1H-indol-3-yl)ethanamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 6h; Inert atmosphere; Reflux;
DOI:10.1021/ml400447v

Reference yield:

: 7042-71-9
4-benzyloxyindole-3-carbaldehyde

: 109249-04-9
2-(4-(benzyloxy)-1H-indol-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / 1 h / Inert atmosphere; Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran; 1: |Henry Nitro Aldol Condensation;
DOI:10.1021/ml400447v