Technology Process of propane-1-sulfonic acid (2-fluoro-3-hydroxymethyl-phenyl)-amide
There total 7 articles about propane-1-sulfonic acid (2-fluoro-3-hydroxymethyl-phenyl)-amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 20 ℃;
for 8h;
Inert atmosphere;
With
Glauber's salt;
In
tetrahydrofuran;
for 12h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / dichloromethane / 20 °C
2.1: water; potassium hydroxide / tetrahydrofuran / Reflux
2.2: pH 2
3.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2 h / 2585.81 Torr
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice
5.1: dichloromethane / 20 °C / Cooling with ice
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere
6.2: 12 h
With
pyridine; lithium aluminium tetrahydride; oxalyl dichloride; water; hydrogen; potassium hydroxide;
20% palladium hydroxide-activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium; 1,2-bis-(chlorodimethylsilyl)ethane / tetrahydrofuran; hexane / 4 h / -78 - 20 °C / Inert atmosphere
1.2: -78 °C
2.1: pyridine / dichloromethane / 20 °C
3.1: water; potassium hydroxide / tetrahydrofuran / Reflux
3.2: pH 2
4.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2 h / 2585.81 Torr
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice
6.1: dichloromethane / 20 °C / Cooling with ice
7.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere
7.2: 12 h
With
pyridine; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; 1,2-bis-(chlorodimethylsilyl)ethane; water; hydrogen; potassium hydroxide;
20% palladium hydroxide-activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
