4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile

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Chemical Name:4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile
CAS No.:848666-15-9
Molecular Formula:C₂₆H₂₄N₆O
Molecular Weight:436.516
Hs Code.:

Synonyms:4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile

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Chemical Property of 4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile

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Technology Process of 4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile

There total 7 articles about 4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848665-66-7
4-benzyloxy-2-(4-nitro-phenyl)-3-oxo-butyronitrile

: 848666-15-9
4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: CH₂Cl₂; diethyl ether

2.1: 8.78 g / NaOEt / ethanol / 3 h / Heating

3.1: 95 percent / H₂ / Pd(OH)2/C / methanol / 14 h / 20 °C / 3102.89 Torr

4.1: NaOAc; AcOH / methanol / 0.25 h

4.2: NaBH₃CN / methanol / 16 h / 25 °C

With hydrogen; sodium ethanolate; sodium acetate; acetic acid; palladium dihydroxide; In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm0510934

Reference yield:

: 4-benzyloxy-3-methoxy-2-(4-nitro-phenyl)-but-2-enenitrile

: 848666-15-9
4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 8.78 g / NaOEt / ethanol / 3 h / Heating

2.1: 95 percent / H₂ / Pd(OH)2/C / methanol / 14 h / 20 °C / 3102.89 Torr

3.1: NaOAc; AcOH / methanol / 0.25 h

3.2: NaBH₃CN / methanol / 16 h / 25 °C

With hydrogen; sodium ethanolate; sodium acetate; acetic acid; palladium dihydroxide; In methanol; ethanol;
DOI:10.1021/jm0510934

Reference yield:

: 848665-67-8
6-benzyloxymethyl-5-(4-nitro-phenyl)-pyrimidine-2,4-diamine

: 848666-15-9
4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / H₂ / Pd(OH)2/C / methanol / 14 h / 20 °C / 3102.89 Torr

2.1: NaOAc; AcOH / methanol / 0.25 h

2.2: NaBH₃CN / methanol / 16 h / 25 °C

With hydrogen; sodium acetate; acetic acid; palladium dihydroxide; In methanol;
DOI:10.1021/jm0510934