Cycloheptanecarboxaldehyde, 1-methoxy- (9CI)

Base Information

• Chemical Name: Cycloheptanecarboxaldehyde, 1-methoxy- (9CI)
• CAS No.: 761411-23-8
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.225
• Mol file: 761411-23-8.mol

Synonyms:1-Methoxycycloheptanecarboxaldehyde

Chemical Property of Cycloheptanecarboxaldehyde, 1-methoxy- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

CID12148228 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cycloheptanecarboxaldehyde, 1-methoxy- (9CI)

There total 3 articles about Cycloheptanecarboxaldehyde, 1-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-ethenyl-1-methoxycycloheptane (761411-15-8) → 1-methoxycycloheptanecarboxaldehyde (761411-23-8)

Guidance literature:

With potassium metaperiodate; osmium(VIII) oxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1007/s00706-004-0163-0

Reference yield:

1-vinylcycloheptanol (6244-47-9) → 1-methoxycycloheptanecarboxaldehyde (761411-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 2 h / Heating

1.2: 87 percent / tetrahydrofuran / Heating

2.1: 56 percent / KIO₄ / OsO₄ / tetrahydrofuran; H₂O / 20 °C

With potassium metaperiodate; sodium hydride; osmium(VIII) oxide; In tetrahydrofuran; water; 2.1: Malaprade reaction;

DOI:10.1007/s00706-004-0163-0

Reference yield:

cycloheptanone (502-42-1) → 1-methoxycycloheptanecarboxaldehyde (761411-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 86 percent / tetrahydrofuran; diethyl ether / -5 - 20 °C

2.1: NaH / tetrahydrofuran / 2 h / Heating

2.2: 87 percent / tetrahydrofuran / Heating

3.1: 56 percent / KIO₄ / OsO₄ / tetrahydrofuran; H₂O / 20 °C

With potassium metaperiodate; sodium hydride; osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; water; 3.1: Malaprade reaction;

DOI:10.1007/s00706-004-0163-0

upstream raw materials:

1-ethenyl-1-methoxycycloheptane

1-vinylcycloheptanol

cycloheptanone

Refernces