(R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide

Base Information

• Chemical Name: (R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide
• CAS No.: 862686-45-1
• Molecular Formula: C₁₅H₂₁N₅O
• Molecular Weight: 287.365

Synonyms:(R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide

Chemical Property of (R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide

Chemical Property:

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Technology Process of (R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide

There total 1 articles about (R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C2HF3O2*C15H21N5O → (R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide (862686-45-1)

Guidance literature:

With macroporous polystyrene carbonate resin; In dichloromethane;

Reference yield: 62.0%

(2Z)-3-(dimethylamino)-2-fluoro-1-(1-isopropyl-2-methyl-1H-imidazol-5-yl)prop-2-en-1-one (862685-76-5) + (R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide (862686-45-1) → (R)-1-{4-[5-fluoro-4-(3-isopropyl-2-methyl-3H-imidazol-4-yl)-pyrimidin-2-ylamino]-phenyl}-pyrrolidine-2-carboxylic acid cylopropylamide

Guidance literature:

In 2-methoxy-ethanol; at 18 - 250 ℃; for 2h;

Reference yield: 36.0%

(R)-1-(4-guanidino-phenyl)pyrrolidine-2-carboxylic acid cyclopropylamide (862686-45-1) + 1-acetyl-4-(2-chloro-4-nitrophenyl)piperazine (101970-40-5) → (R)-1-{4-[4-(3-isopropyl-2-methyl-3H-imidazol-4-yl)-pyrimidin-2-ylamino]-phenyl}-pyrrolidine-2-carboxylic acid cyclopropylamide

Guidance literature:

In 2-methoxy-ethanol; at 18 - 250 ℃; for 2h;

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