methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d₂

Base Information

• Chemical Name: methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d₂
• CAS No.: 1489126-72-8
• Molecular Formula: C₂₅H₃₁NO₃
• Molecular Weight: 395.51

Synonyms:methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d₂

Chemical Property of methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d₂

Chemical Property:

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Technology Process of methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d₂

There total 6 articles about methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H9(2)H2ClO3 + 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylamine (92050-16-3) → methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d2 (1489126-72-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15.5h; Cooling with ice;

DOI:10.1248/cpb.c13-00356

Reference yield:

3-(4-carboxyphenyl)propionic acid (38628-51-2) → methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d2 (1489126-72-8)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen; sodium carbonate; water-d2 / 48 h / 100 °C / 760.05 Torr

2: thionyl chloride / 16 h / 0 - 20 °C

3: thionyl chloride; N,N-dimethyl-formamide / benzene / 6 h / Reflux

4: triethylamine / dichloromethane / 15.5 h / 20 °C / Cooling with ice

With thionyl chloride; palladium 10% on activated carbon; hydrogen; water-d2; sodium carbonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; benzene;

DOI:10.1248/cpb.c13-00356

Reference yield:

methyl 3-(4-carboxyphenyl)propionate-3,3-d2 (1489126-65-9) → methyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate-3,3-d2 (1489126-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / benzene / 6 h / Reflux

2: triethylamine / dichloromethane / 15.5 h / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; benzene;

DOI:10.1248/cpb.c13-00356

upstream raw materials:

4-Carboxybenzaldehyde

trans-p-carboxycinnamic acid

3-(4-carboxyphenyl)propionic acid

3-(4-carboxyphenyl)propionic acid-3,3-d₂

Downstream raw materials:

3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionic acid-3,3-d₂

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