1-(2-CHLOROPHENYL)-2-BROMOETHANOL

Base Information

• Chemical Name: 1-(2-CHLOROPHENYL)-2-BROMOETHANOL
• CAS No.: 72702-57-9
• Molecular Formula: C8H8 Br Cl O
• Molecular Weight: 235.508
• Mol file: 72702-57-9.mol

Synonyms:Benzylalcohol, a-(bromomethyl)-o-chloro- (6CI);1-(o-Chlorophenyl)-2-bromoethanol; 2-Bromo-1-(2-chlorophenyl)ethanol

Chemical Property of 1-(2-CHLOROPHENYL)-2-BROMOETHANOL

Chemical Property:

• Boiling Point: 292.6±25.0 °C(Predicted)
• PKA: 12.63±0.20(Predicted)
• PSA: 20.23000
• Density: 1.617±0.06 g/cm3(Predicted)
• LogP: 2.76830

Purity/Quality:

98.5% ^*data from raw suppliers

1-(2-CHLOROPHENYL)-2-BROMOETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-CHLOROPHENYL)-2-BROMOETHANOL

There total 4 articles about 1-(2-CHLOROPHENYL)-2-BROMOETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

2-chlorophenacyl bromide (5000-66-8) → 2-Bromo-1-(2-chlorophenyl)ethan-1-ol (72702-57-9)

Guidance literature:

With potassium borohydride; In ethanol; water; at 20 ℃; for 0.25h; Cooling with ice; Large scale;

Reference yield: 91.0%

2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) → 2-Bromo-1-(2-chlorophenyl)ethan-1-ol (72702-57-9)

Guidance literature:

With 5,5-dibromohydantoin; water; In acetone; at 20 ℃; for 2h; Time;

Reference yield: 74.0%

→ 2-Bromo-1-(2-chlorophenyl)ethan-1-ol (72702-57-9)

Guidance literature:

upstream raw materials:

2-chlorophenacyl bromide

1-(2-chlorophenyl)ethanone

2-chlorostyrene

Downstream raw materials:

o-chlorostyrene oxide

C₁₉H₁₉ClN₂O₂

C₂₄H₂₇ClN₂O₄

2-bromo-1-(2-chlorophenyl)ethan-1-ol

Refernces

• 1、 Fonseca, Thiago de Sousa,Vega, Kimberly Benedetti,da Silva, Marcos Reinaldo,de Oliveira, Maria da Concei??o Ferreira,de Lemos, Telma Leda Gomes,Contente, Martina Letizia,Molinari, Francesco,Cespugli, Marco,Fortuna, Sara,Gardossi, Lucia,de Mattos, Marcos Carlos. "Lipase mediated enzymatic kinetic resolution of phenylethyl halohydrins acetates: A case of study and rationalization". . . Retrieved 2020/02/18.
• 2、 -. "Preparation method of tulobuterol". Paragraph 0042-0049. . Retrieved 2020/06/16.