4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid

Base Information

Chemical Name:4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid
CAS No.:127045-73-2
Molecular Formula:C₁₈H₁₄F₃NO₄
Molecular Weight:365.309
Hs Code.:

Synonyms:4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid

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Chemical Property of 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid

Chemical Property:

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Technology Process of 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid

There total 11 articles about 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 127045-64-1
ethyl 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoate

: 127045-73-2
4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; ethanol; for 2h; Ambient temperature;
DOI:10.1248/cpb.42.2063

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 127045-73-2
4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 91 percent / thionyl chloride / 1 h / Heating

2: NaH / dimethylformamide / 12 h / Ambient temperature

3: 1.) TFA / 1.) RT, 20 h, 2.) toluene, reflux, 2 h

4: 91 percent / diethyl ether; petroleum ether / Ambient temperature

5: 95 percent / acetic anhydride / dimethylsulfoxide / 2 h / Ambient temperature

6: 69 percent / dimethylsulfoxide / 0.5 h / 15 - 20 °C

7: 92 percent / TFA, anisole / 2 h / Ambient temperature

8: Et₃N / acetone / 1.5 h / -25 - -20 °C

9: NaN₃ / H₂O; acetone / 0.5 h / 5 °C

10: dioxane / 2 h / Heating

11: 92 percent / 1 N aq. NaOH / ethanol; dioxane / 2 h / Ambient temperature

With sodium hydroxide; thionyl chloride; sodium azide; acetic anhydride; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; Petroleum ether;
DOI:10.1248/cpb.42.2063

Reference yield:

: 122894-73-9
ethyl 2,3,4,5-tetrafluorobenzenecarboxylate

: 127045-73-2
4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: NaH / dimethylformamide / 12 h / Ambient temperature

2: 1.) TFA / 1.) RT, 20 h, 2.) toluene, reflux, 2 h

3: 91 percent / diethyl ether; petroleum ether / Ambient temperature

4: 95 percent / acetic anhydride / dimethylsulfoxide / 2 h / Ambient temperature

5: 69 percent / dimethylsulfoxide / 0.5 h / 15 - 20 °C

6: 92 percent / TFA, anisole / 2 h / Ambient temperature

7: Et₃N / acetone / 1.5 h / -25 - -20 °C

8: NaN₃ / H₂O; acetone / 0.5 h / 5 °C

9: dioxane / 2 h / Heating

10: 92 percent / 1 N aq. NaOH / ethanol; dioxane / 2 h / Ambient temperature

With sodium hydroxide; sodium azide; acetic anhydride; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; Petroleum ether;
DOI:10.1248/cpb.42.2063