(S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride

Base Information

• Chemical Name: (S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride
• CAS No.: 253138-02-2
• Molecular Formula: C₂₁H₂₄N₂O₄*ClH
• Molecular Weight: 404.894
• Mol file: 253138-02-2.mol

Synonyms:(S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride

Chemical Property of (S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride

There total 1 articles about (S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Boc-Lys(Fmoc)-OH (84624-27-1) → (S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride (253138-02-2,367272-52-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

(S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride (253138-02-2,367272-52-4) + trityl chloride (76-83-5) → 9H-fluoren-9-ylmethyl N-[(5S)-6-amino-6-oxo-5-(tritylamino)hexyl]carbamate (1596360-17-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h; Cooling;

DOI:10.1016/j.bmc.2014.02.002

Reference yield:

(S)-2-amino-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid hydrochloride (253138-02-2,367272-52-4) + C25H20N6O6 → 9H-fluoren-9-ylmethyl N-[(5S)-5-[[6-[[3-(3-carbamoyl-4-phenoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]-5-cyano-pentyl]carbamate (1596360-81-4)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h;

DOI:10.1016/j.bmc.2014.02.002

upstream raw materials:

Boc-Lys(Fmoc)-OH

Downstream raw materials:

9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

N-[(1S)-5-amino-1-cyano-pentyl]-6-[[3-(4-fluorophenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carboxamide

9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-methoxyphenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

N-[(1S)-5-Amino-1-cyano-pentyl]-6-[[3-(4-methoxyphenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carboxamide