methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

Base Information

Chemical Name:methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate
CAS No.:1445787-15-4
Molecular Formula:C₂₇H₂₇N₅O₅
Molecular Weight:501.542
Hs Code.:

Synonyms:methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

Suppliers and Price of methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

There total 3 articles about methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.8%

: 103797-22-4
methyl 2-methyl-2-(3-nitrophenyl)propanoate

: 1374867-83-0
4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

: 1445787-15-4
methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

Guidance literature:: methyl 2-methyl-2-(3-nitrophenyl)propanoate; With palladium 10% on activated carbon; hydrogen; acetic acid; for 2h; under 2068.65 Torr;

4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide; at 20 ℃;

Reference yield:

: 1374867-81-8
7-bromo-4-chloroquinoline-3-carboxamide

: 1445787-15-4
methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 2 h / 2068.65 Torr

2.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; water;

Reference yield:

: 860205-92-1,154326-11-1
7-bromo-4-hydroxy-3-quinolinecarboxylic acid

: 1445787-15-4
methyl 2-(3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / Reflux

1.2: 2 h / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

3.1: hydrogen; acetic acid; palladium 10% on activated carbon / 2 h / 2068.65 Torr

3.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; water;