[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester
CAS No.:1025933-74-7
Molecular Formula:C₂₂H₂₃F₈N₅O₃
Molecular Weight:557.444
Hs Code.:

[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8<i>H</i>-[1,2,4]triazolo[4,3-<i>a</i>]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

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Technology Process of [3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

There total 8 articles about [3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 837430-17-8
3-(pentafluoroethyl)-1,2,4-triazolo[4,3-a]pyrazine

: 1025933-74-7
[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / H₂ / Pd/C / ethanol / 18 h / 20 °C / atmospheric pressure

2: HOBT; EDC; DIPEA / dimethylformamide / 20 °C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0493156

Reference yield:

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 837430-19-0
3-(pentafluoroethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine

: 1025933-74-7
[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0493156

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1025933-74-7
[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. HCl / acetonitrile / 72 h / 20 °C

1.2: 2.41 g / triethylamine / CH₂Cl₂ / 16 h / 20 °C

2.1: aq. LiOH / tetrahydrofuran / 20 °C

3.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C

3.2: 0.36 g / diethyl ether / 1 h

4.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication

5.1: HOBT; EDC; DIPEA / dimethylformamide / 20 °C

With hydrogenchloride; lithium hydroxide; silver benzoate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0493156