N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one

Base Information

• Chemical Name: N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one
• CAS No.: 231606-11-4
• Molecular Formula: C₂₀H₂₁Cl₂NO
• Molecular Weight: 362.299
• Mol file: 231606-11-4.mol

Synonyms:N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one

Chemical Property of N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one

There total 2 articles about N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C20H21Cl2NO (231606-12-5) → N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one (231606-11-4)

Guidance literature:

With N,N,N',N'',N'''-pentamethyldiethylenetriamine; sodium carbonate; copper dichloride; ascorbic acid; In ethanol; ethyl acetate; at 35 ℃; for 8h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1002/adsc.201300132

Reference yield:

N-benzyl-2,2-dichloro-N-(3-phenyl-allyl)-butyramide → N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one (231606-11-4)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; copper(l) chloride; In acetonitrile; for 20h; Yield given;

DOI:10.1016/S0040-4020(99)00247-1

Reference yield:

N-benzyl-3-chloro-3-ethyl-4-<(α-chloro)-benzyl>-pyrrolidin-2-one (231606-11-4) → trans N-benzyl-3-ethyl-4-benzyl-pyrrolidin-2-one + (3R,4S)-1,4-Dibenzyl-3-ethyl-pyrrolidin-2-one

Guidance literature:

With acetic acid; zinc; at 80 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(99)00247-1

upstream raw materials:

C₂₀H₂₁Cl₂NO

Downstream raw materials:

cis-3-benzyl-2-ethyl-γ-butyrolactam

trans-3-benzyl-2-ethyl-γ-butyrolactam