N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide
CAS No.:1029537-76-5
Molecular Formula:C₂₇H₃₂N₂O₅S
Molecular Weight:496.627
Hs Code.:

Synonyms:N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide

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Chemical Property of N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide

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Technology Process of N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide

There total 3 articles about N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1029537-68-5
N-allyl-N-{(E)-3-[2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-oxoethoxy]propenyl}-4-methylbenzenesulfonamide

: C₂₇H₃₂N₂O₅S

: C₂₇H₃₂N₂O₅S

: 1029537-76-5
N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; stereoselective reaction;
DOI:10.1002/chem.201003265

Reference yield:

: 950777-59-0
(E)-N-allyl-N-(3-hydroxyprop-1-en-1-yl)-4-methylbenzenesulfonamide

: C₂₇H₃₂N₂O₅S

: C₂₇H₃₂N₂O₅S

: 1029537-76-5
N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; toluene / 1 h / 20 °C

2: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; water; toluene; 2: Wittig rearrangement;
DOI:10.1002/chem.201003265

Reference yield:

: 50487-71-3
4-methyl-N-(2-propenyl)benzenesulfonamide

: C₂₇H₃₂N₂O₅S

: C₂₇H₃₂N₂O₅S

: 1029537-76-5
N-allyl-N-{(R)-1-[(S)-2-((3aR,8aS)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-1-hydroxy-2-oxo-ethyl]allyl}-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / acetonitrile / 2 h / 0 °C

2: diisobutylaluminium hydride / hexane; dichloromethane / 0.33 h / -78 °C

3: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; toluene / 1 h / 20 °C

4: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; tetra(n-butyl)ammonium hydrogensulfate; diisobutylaluminium hydride; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile; 4: Wittig rearrangement;
DOI:10.1002/chem.201003265