(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

Base Information

Chemical Name:(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide
CAS No.:328093-03-4
Molecular Formula:C₂₇H₃₆IN₃O₄Si
Molecular Weight:621.591
Hs Code.:

(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

Synonyms:(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

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Chemical Property of (S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

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Technology Process of (S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

There total 20 articles about (S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 328093-38-5
(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(E),4-dienoic acid, N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

: 328093-03-4
(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

Guidance literature:: With 1,2,2,6,6-pentamethylpiperidine; In N,N-dimethyl acetamide; at 80 ℃;
DOI:10.1002/1521-3773(20001215)39:24<4596::AID-ANIE4596>3.0.CO;2-F

Reference yield:

: 615-43-0
2-iodophenylamine

: 328093-03-4
(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

Guidance literature:: Multi-step reaction with 6 steps

1: 1-methyl-2-chloropyridinium iodide

2: NaH

3: TBAF

4: tBuOK

5: 1,2,2,6,6-pentamethylpiperidine / N,N-dimethyl-acetamide / 80 °C

With 1,2,2,6,6-pentamethylpiperidine; potassium tert-butylate; tetrabutyl ammonium fluoride; 2-chloro-1-methyl-pyridinium iodide; sodium hydride; In N,N-dimethyl acetamide; 4: Dess-Martin oxidation;
DOI:10.1002/1521-3773(20001215)39:24<4596::AID-ANIE4596>3.0.CO;2-F

Reference yield:

: 148901-34-2
methyl 3-hydroxy-5-methyl-2-methylene-4-hexenoate

: 328093-03-4
(S)-2-(1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-3(Z)-ylidenemethyl)-5-methylhexa-2(Z),4-dienoic acid N-(2-iodophenyl)-N-[2-(trimethylsilyl)ethoxymethyl]amide

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine

2: MgBr₂*OEt₂

3: DIEA

4: LiOH

5: 1-methyl-2-chloropyridinium iodide

6: NaH

7: TBAF

8: tBuOK

9: 1,2,2,6,6-pentamethylpiperidine / N,N-dimethyl-acetamide / 80 °C

With pyridine; 1,2,2,6,6-pentamethylpiperidine; lithium hydroxide; potassium tert-butylate; tetrabutyl ammonium fluoride; 2-chloro-1-methyl-pyridinium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; magnesium bromide; In N,N-dimethyl acetamide; 9: Dess-Martin oxidation;
DOI:10.1002/1521-3773(20001215)39:24<4596::AID-ANIE4596>3.0.CO;2-F