3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

Base Information

Chemical Name:3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone
CAS No.:130291-50-8
Molecular Formula:C₁₉H₂₄N₂O₇S
Molecular Weight:424.475
Hs Code.:

3-<2-(Methoxycarbonyl)-2-<N-(methoxycarbonyl)-N-methylamino>ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

Synonyms:3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

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Chemical Property of 3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

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Technology Process of 3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

There total 3 articles about 3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 130291-48-4
2-(Methoxycarbonyl-methyl-amino)-3-[2-oxo-3-phenylsulfanyl-1-(toluene-4-sulfonyl)-piperidin-3-yl]-propionic acid methyl ester

: 130291-50-8
3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jo00047a031

Reference yield:

: 143076-20-4
N-(p-Toluenesulfonyl)-3-(phenylthio)-2-piperidone

: 130291-50-8
3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) KN(TMS)2 / 1) THF, -60 deg C, 2) THF, -30 to -20 deg C, 1 h

2: 88 percent / m-CPBA, aq.NaHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

With potassium hexamethylsilazane; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jo00047a031

Reference yield:

: 23438-61-1
1-(toluene-4-sulfonyl)piperidin-2-one

: 130291-50-8
3-<2-(Methoxycarbonyl)-2-ethyl>-2-(p-toluenesulfonyl)-5,6-dihydro-2(1H)-pyridinone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / KN(TMS)2 / tetrahydrofuran; toluene / 0.5 h / -60 °C

2: 1) KN(TMS)2 / 1) THF, -60 deg C, 2) THF, -30 to -20 deg C, 1 h

3: 88 percent / m-CPBA, aq.NaHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

With potassium hexamethylsilazane; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo00047a031